Publications

Abstract The purpose of this article is to present and discuss a historical house project that was transposed into virtual reality, to be preserved as digital cultural heritage. The Matosinhos House, in Portugal, is part of a residential project designed by the architect Alvaro Siza Vieira in 1955-56, is the historical house that was chosen as case study. The article displays the historical significance of the project, as well as the method applied to transpose it into virtual reality. The goal is to promote access to digital cultural heritage based on reliable and accurate interpretation of the collected data.

Abstract The effect of the anion on the electrical conductivity of ionic liquids was explored by a high-precision study of the temperature dependence (283–333 K) of the electrical conductivity of ten ILs based on the 1-butyl-3-methylimidazolium cation, [C4C1im]+. The following trend was observed for the molar conductivity at the reference temperature of 298.15 K: Ac < PF6− < BETI < OTf < TFA < BF4− < FAP < NTf2 < FSI < DCA. The molar conductivity at infinite temperature, AΛ, and the energy barrier, EΛ, derived from the Vogel–Fulcher–Tammann equation (VFT) fitting were found to correlate well with the shape/size/dynamics and cohesive energy/charge localization of the studied ions. An extensive revision and comparison with the available experimental electrical conductivity data for the studied ionic liquids is also presented. Additionally, this work presents a detailed description, testing, and evaluation of performance results of a new system/methodology for the high-precision measurement of the electrical conductivity of ionic fluids, designed to minimize the size of the ionic liquid sample and in situ degassing of the sample. The measuring system is based on a high-precision LCR meter and a conductivity cell system designed to ensure the vacuum and gastightness of the sample container. The high-precision temperature control is ensured by a customized thermal chamber based on a heating and cooling Peltier system. The electrical conductivity data were corrected for the effect of solution polarization by extrapolating the resistance to infinite frequency. The accuracy and resolution of the system were evaluated by measuring the conductivity of the reference ionic liquid, [C6C1im][NTf2] which was found to be in excellent agreement with the recommended data. © 2025 The Author(s)

Abstract This study demonstrates the efficacy of ionic liquid (IL)-assisted vapor deposition in achieving high-quality and distinctive crystal film growth of two organic semiconductors (OSCs): a carbazole derivative (TCB) and a phenylamine derivative (TDAB). ILs with different wetting properties (short-chain [C2C1im][NTf2] and long-chain [C8C1im][NTf2]) and engineered shapes (microdroplets and coalesced film) were utilized as solvents in a vacuum. Through a meticulously designed experimental strategy, encompassing both sequential and simultaneous deposition of the IL and the OSC, this study unveils the pivotal role of ILs in shaping the crystallization behavior of the organic compound. Differential scanning calorimetry, polarized light microscopy, high-resolution scanning electron microscopy, and X-ray diffraction were employed for the films' thermal, morphological, and structural characterization. Thin films of TDAB exhibit crystallinity and a greater tendency to grow tridimensionally, forming giant pillars. However, the typical vertical growth of TDAB on solid substrates is altered when deposition occurs on surfaces coated with ILs. The IL promotes the lateral growth of nanostructures. The experimental results reveal variations in film morphology and coverage influenced by the cation alkyl chain length of the IL. In contrast to TDAB, TCB films are amorphous when thermally evaporated on solid substrates. Notably, IL-assisted vapor deposition induces the crystallization of TCB. Furthermore, TCB films deposited on coalesced IL films exhibit enhanced crystallinity and homogeneous horizontal growth, representing a significant finding in the context of thin film deposition and semiconductor device fabrication.

Abstract Extensive research has focused on films formed by pure ionic liquids (ILs). However, growing interest in IL mixtures and their synergistic properties presents new opportunities for targeted applications and fundamental scientific investigations. This study explores the morphology of films composed of mixtures of two ILs, [C2C1im][OTf] and [C8C1im][OTf], co-deposited via physical vapor deposition (PVD)/vacuum thermal evaporation. The primary objective was understanding how varying the IL ratio influences droplet formation, surface coverage, and overall film structure. Thin-film growth was examined on glass substrates coated with indium tin oxide (ITO) and ITO/glass surfaces coated with metallic films (Au and Ag). Film morphology was characterized using optical and high-resolution scanning electron microscopy (SEM), while elemental composition was analyzed via X-ray photoelectron spectroscopy (XPS). The results show that IL mixture morphology is strongly influenced by both IL composition and substrate type. Increasing [C8C1im][OTf] content led to larger microstructures due to improved wetting, particularly on Au surfaces, resulting in nearly fully coalesced films. Metallic surfaces near ITO significantly impacted droplet behavior, with ILs exhibiting a strong affinity for metals, especially when the long-chain IL dominated the mixture. The IL-assisted crystallization of rubrene, a high-performance organic semiconductor (OSC) that typically exhibits poor crystallinity when deposited via PVD, highlights the potential of IL mixtures to enhance organic film quality. X-ray diffraction (XRD) confirmed that [C2C1im][OTf] and [C8C1im][OTf] mixtures significantly improved rubrene crystallinity, demonstrating their potential to create an optimal environment for OSC solubility and crystallization.

Abstract The impact of nanostructuration on the transport properties of ionic liquids (ILs) was explored by a systematic and high-resolution study of the temperature dependence of the viscosity and electrical conductivity of seven ILs homolog series: [C(n)C(1)im]BF4, [C(n)C(1)im]PF6, [C(n)C(1)im][OTf], [C(n)C(1)im][FAP], [C(n)C(1)im][NTf2], [CnC(1)pyr][NTf2], [Cnpy][NTf2]. The increase of the alkyl chain length was found to increase the viscosity and decrease the molar conductivity due to a reduction of the overall mobility of the liquid and enhancement of the van der Waals interactions. The temperature dependency of transport properties was fitted to the Vogel-Fulcher-Tammann equation (VFT), and the energy barrier and pre-exponential coefficients were derived. The obtained results highlight the trendshift (n = 6-7) in the profile of the transport properties, which is a reflection of the intensification of nanostructuration and describes the transition from a liquid with a strong ionic character to a nanostructured liquid dominated by the hydrophobic domain. The derived energy barriers were found to correspond to around 0.2-0.35 of the cohesive interactions of the ionic liquids, with the spherical anions BF4- and PF6- showing a higher fraction than the more stretched and larger anions, such as NTf2. This fraction was found to not be affected by the alkyl chain length. The increase of the nonpolar region was also reflected in a more pronounced deviation from the ideal Walden relation. This highlights the increased complexity of the electric conductivity when compared with viscosity due to the heterogeneity of charge distribution, revealing the impact of ionic surface-volume ratio and anion-cation size ratio.

Abstract Thin films of ionic liquids (ILs) have gained significant attention due to their unique properties and broad applications. Extensive research has focused on studying the influence of ILs' chemical composition and substrate characteristics on the structure and morphology of IL films at the nano- and mesoscopic scales. This study explores the impact of carbon-coated surfaces on the morphology and wetting behavior of a series of alkylimidazolium-based ILs. Specifically, this work investigates the effect of carbon coating on the morphology and wetting behavior of short-chain ([C(2)C(1)im][NTf2] and [C(2)C(1)im][OTf]) and long-chain ([C(8)C(1)im][NTf2] and [C(8)C(1)im][OTf]) ILs deposited on indium tin oxide (ITO), silver (Ag), and gold (Au) substrates. A reproducible vapor deposition methodology was utilized for the deposition process. High-resolution scanning electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy were used to analyze the morphological and structural characteristics of the substrates and obtained IL films. The experimental data revealed that the IL films deposited on carbon-coated Au substrates showed minor changes in their morphology compared to that of the films deposited on clean Au surfaces. However, the presence of carbon coatings on the ITO and Ag surfaces led to significant morphological alterations in the IL films. Specifically, for short-chain ILs, the carbon film surface induced 2D growth of the IL film, followed by subsequent island growth. In contrast, for long-chain ILs deposited on carbon surfaces, layer-by-layer growth occurred without island formation, resulting in highly uniform and coalesced IL films. The extent of morphological changes observed in the IL films was found to be influenced by two crucial factors: the thickness of the carbon film on the substrate surface and the amount of IL deposition.

Abstract The thermodynamic properties of ionic liquids (ILs) bearing alkylsilane and alkylsiloxane chains, as well as their carbon-based analogs, were investigated. Effects such as the replacement of carbon atoms by silicon atoms, the introduction of a siloxane linkage, and the length of the alkylsilane chain were explored. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were used to study the thermal and phase behavior (glass transition temperature, melting point, enthalpy and entropy of fusion, and thermal stability). Heat capacity was obtained by high-precision drop calorimetry and differential scanning microcalorimetry. The volatility and cohesive energy of these ILs were investigated via the Knudsen effusion method coupled with a quartz crystal microbalance (KEQCM). Gas phase energetics and structure were also studied to obtain the gas phase heat capacity as well as the energy profile associated with the rotation of the IL side chain. The computational study suggested the existence of an intramolecular interaction in the alkylsiloxane-based IL. The obtained glass transition temperatures seem to follow the trend of chain flexibility. An increase of the alkylsilane chain leads to a seemingly linear increase in molar heat capacity. A regular increment of 30 JK-1mol(-1) in the molar heat capacity was found for the replacement of carbon by silicon in the IL alkyl chain. The alkylsilane series was revealed to be slightly more volatile than its carbon-based analogs. A further increase in volatility was found for the alkylsiloxane-based IL, which is likely related to the decrease of the cohesive energy due to the existence of an intramolecular interaction between the siloxane linkage and the imidazolium headgroup. The use of Si in the IL structure is a suitable way to significantly reduce the IL's viscosity while preserving its large liquid range (low melting point and high thermal stability) and low volatilities.

Abstract This work presents a comprehensive study exploring the thermodynamics of the solid phase of a series of phenylimidazoles, encompassing experimental measurements of heat capacity, volatility, and thermal behavior. The influence of successive phenyl group insertions on the imidazole ring on thermodynamic properties and supramolecular behavior was thoroughly examined through the evaluation of 2-phenylimidazole (2-PhI), 4-phenylimidazole (4-PhI), 4,5-diphenylimidazole (4,5-DPhI), and 2,4,5-triphenylimidazole (2,4,5-TPhI). Structural correlations between molecular structure and thermodynamic properties were established. Furthermore, the investigation employed UV-vis spectroscopy and quantum chemical calculations. Additive effects arising from the introduction of phenyl groups were found through the analysis of the solid-liquid and solid-gas equilibria, as well as heat capacities. A good correlation emerged between the thermodynamic properties of sublimation and the molar volume of the unit cell, evident across 2-PhI, 4,5-DPhI, and 2,4,5-TPhI. In contrast to its isomer 2-PhI, 4-PhI exhibited greater cohesive energy due to the stronger N-HN intermolecular interactions, leading to the disruption of coplanar geometry in the 4-PhI molecules. The observed higher entropies of phase transition (fusion and sublimation) are consistent with the higher structural order observed in the crystalline lattice of 4-PhI.

Abstract This work studies the formation of deep eutectic solvents formed by one active pharmaceutical ingredient (quinine, pyrimethamine, or 2-phenylimidazopyridine) and a second component potentially acting as an excipient (betaine, choline chloride, tetramethylammonium chloride, thymol, menthol, gallic acid, vanillin, acetovanillone, 4-hydroxybenzaldehyde, syringaldehyde, propyl gallate, propylparaben, or butylated hydroxyanisole), aiming to address challenges regarding drug solubility, bioavailability, and permeability. A preliminary screening was carried out using the thermodynamic model COSMO-RS, narrowing down the search to three promising excipients (thymol, propyl gallate, and butylated hydroxyanisole). Nine solid-liquid equilibrium (SLE) phase diagrams were experimentally measured combining the three model drugs with the screened excipients, and using a combination of a visual melting method and differential scanning calorimetry. Negative deviations from thermodynamic ideality were observed in all nine systems. Furthermore, a total of four new cocrystals were found, with powder and single crystal X-ray diffraction techniques being employed to verify their unique diffraction patterns. In the thermodynamic modelling of the SLE diagrams, two COSMO-RS parametrizations (TZVP and TZVPD-FINE) were also applied, though neither consistently delivered a better description over the other.

Abstract A systematic synthetic study was performed to explain the usual trend in selectivity towards multi-coupling, over mono-coupling, in Suzuki-Miyaura reactions. This preference was observed under different reaction conditions: for various halobenzenes, using substituents on the boronic acid, and changing the catalyst and temperature. Moreover, this reaction selectivity was found to increase for more reactive systems towards oxidative addition and more diluted media. The results constitute experimental evidence that the formation of the totally substituted coupling product is kinetically favoured by a reaction path location-the proximity between the regenerated catalyst and the newly formed coupling intermediate promotes the subsequent reaction.