Degree: Doctor



Showing 5 latest publications. Total publications: 344
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1. Phytochemical Compounds and Anticancer Activity of Cladanthus mixtus Extracts from Northern Morocco, El Mihyaoui, A; Charfi, S; Erbiai, EH; Pereira, M; Duarte, D; Vale, N; Candela Castillo, ME; Badoc, A; Lamarti, A; Esteves da Silva, JCG Arnao, MB in Cancers, 2023, ISSN: 2072-6694,  Volume: 15, 
Article,  Indexed in: crossref, scopus  DOI: 10.3390/cancers15010152 P-00X-P3N
Abstract Many of the chemotherapeutic drugs for the treatment of cancer are molecules identified and isolated from plants or their synthetic derivatives. This work aimed to identify the bioactive compounds using LC-MS and GC-MS and to evaluate the anticancer activity of the methanolic extracts of roots, stems, leaves, and flowers from Cladanthus mixtus. The anticancer activity was evaluated in vitro against two cancer cell lines: human breast carcinoma (MCF-7) and human prostate carcinoma (PC-3), using the MTT assay and microscopic observation. A human normal lung fibroblast (MRC-5) was included to determine the extract’s safety for non-tumoral cells. The chemical composition results by LC-MS analysis revealed the presence of 24 phenolic compounds. Furthermore, GC-MS analysis allowed the identification of many biomolecules belonging to terpenoids, esters, alcohols, alkanes, fatty acids, organic acids, benzenes, phenols, ketones, carbonyls, amines, sterols, and other groups. The findings suggest that the majority of C. mixtus extracts have antiproliferative activity against two cancer cell lines, MCF-7 and PC-3, and one non-tumoral cell line, MRC-5. The activity was dose-dependent, and the highest effect was obtained with leaf extract in the two cancer cell lines. Moreover, these extracts demonstrated an acceptable toxicological profile against normal cells. Overall, C. mixtus extracts revealed promising antitumor properties provided by their phytochemical composition. © 2022 by the authors.

2. Evaluation of the carbon footprint of the life cycle of wine production: A review, Pinto da Silva, L Esteves da Silva, JC in Cleaner and Circular Bioeconomy, 2022, ISSN: 2772-8013,  Volume: 2, 
Article,  Indexed in: crossref  DOI: 10.1016/j.clcb.2022.100021 P-00W-Y1P

3. Chemiluminescent Self-Activating Photosensitizers for Selective Anticancer Therapy, Magalhães, CM; González-Berdullas, P; Silva, JCGEd Silva, LPd in ECMC 2022, 2022,
Proceedings Paper,  Indexed in: crossref  DOI: 10.3390/ecmc2022-13174 P-00X-P3P

4. UV-Based Advanced Oxidation Processes of Remazol Brilliant Blue R Dye Catalyzed by Carbon Dots, Cardoso, IMF; Cardoso, RMF; da Silva, LP da Silva, JCGE in NANOMATERIALS, 2022, Volume: 12, 
Article,  Indexed in: crossref, wos  DOI: 10.3390/nano12122116 P-00W-RHD
Abstract UV-based advanced oxidation processes (AOPs) (UV/H2O2 and UV/S2O82-) with a titanium(IV)-doped carbon dot, TiP-CD, as a catalyst were developed for the decomposition of Remazol Brilliant Blue R (Reactive Blue 19), an anthraquinone textile dye (at T = 25 degrees C and pH = 7). The Ti-CD, with marked catalytic UV properties, was successfully synthesized by the one-pot hydrothermal procedure, using L-cysteine as carbon precursor, ethylenediamine as nitrogen source, PEG (polyethylene glycol) as a capping agent, and titanium(IV) isopropoxide (precursor of TiO2 doping). Contrary to azo dyes (methyl orange, orange II sodium salt, and reactive black 5), which achieved complete degradation in a time interval less than 30 min in the developed AOP systems (UV/H2O2, UV/S2O82-, and UV/TiO2), the RBB-R showed relatively low degradation rates and low discoloration rate constants. In the presence of the catalyzer, the reaction rate significantly increased, and the pseudo-first-order rate constants for the RBB-R discoloration were UV/3.0 mM H2O2/TIP-CD-0.0330 min(-1) and UV/1.02 mM S2O82-/TIP-CD-0.0345 min(-1).

5. Photocatalytic removal of pharmaceutical water pollutants by TiO2-Carbon dots nanocomposites: A review, Sendao, RMS; da Silva, JCGE da Silva, LP in CHEMOSPHERE, 2022, ISSN: 0045-6535,  Volume: 301, 
Review,  Indexed in: crossref, scopus, wos  DOI: 10.1016/j.chemosphere.2022.134731 P-00W-EXY
Abstract Pharmaceuticals are becoming increasingly more relevant water contaminants, with photocatalysts (such as TiO2) being a promising approach to remove these compounds from water. However, TiO2 has poor sunlight harvesting capacity, low photonic efficiency, and poor adsorption towards organic pollutants. One of the emerging strategies to enhance the photocatalytic performance of TiO2 is by conjugating it with fluorescent carbon dots. Herein, we performed a critical review of the development of TiO2 - carbon dots nanocomposites for the photocatalytic removal of pharmaceuticals. We found that carbon dots can improve the photocatalytic efficiency of the resulting nanocomposites, mostly due to increasing the adsorption of organic pollutants and enhancing the absorption in the visible range. However, while this approach shows significant promise, we also identified and discussed several aspects that need to be addressed before this strategy could be more widely used. We hope that this review can guide future studies aiming to the development of enhanced photocatalytic TiO2 - carbon dots nanocomposites.