Publications

Abstract Nutrition has crucial effects and a significant role in disease prevention. Recently, nutraceuticals have attracted much attention in scientific research due to their pleiotropic effects and relatively non-toxic behavior. Among the biological effects displayed by plants belonging to the Lamiaceae family, such as antibacterial, anticancer, anti-inflammatory, and anticholinesterase, sage is well known for its antioxidant properties and is a rich source of numerous compounds that are biologically active, amongst them polyphenols, with more than 160 types identified. In this review we summarized some of the significant studies published in the last decade reporting the most employed extraction methods and the different assays that are useful for establishing the antioxidant properties of some sage species. Even though the scientific literature contains plenty of data regarding the antioxidant properties of many sage species, further studies are needed in order to gain a deeper understanding of the mechanism of action and the compounds responsible for their antioxidant activity. Finally, it should be taken into account that the data on the antioxidant properties of sage extracts are often difficult to compare with each other, since a series of variables in the extraction procedures, the type of assay used, and standardization may affect the final result.

Abstract As artificial intelligence driver monitoring systems gain momentum in intelligent mobility, it is critical to analyse how distraction is defined and induced. This systematic review was specifically focused on studies conducted in driving simulators. A Boolean query was iteratively developed to retrieve articles from Scopus that fulfil the following criteria: (1) being an empirical study, (2) addressing driver distraction, (3) using a driving simulator, (4) aiming at developing an artificial intelligence monitoring system. After screening, 34 articles remained and were analysed according to four general themes: definition of distraction, characteristics of the scenarios used in the driving simulator, sampling of participants, and procedures. Results showed that the most common definitions of distraction consider it as a shift in the driver’s attention towards a secondary task, which implicates in a degradation of the execution of the primary task (i.e., driving the vehicle), and, consequently, a reduction in driving safety. Most articles described the scenarios used in the simulator in greater detail and, in some cases, variations in traffic density, visibility, and environmental conditions were observed. Furthermore, scripted critical events in the scenario (e.g., car in front of the participant breaking) were also used. Recruitment and samples varied greatly between studies, with the smallest population consisting of two and the largest of 97 participants. Despite the sample size, participants still needed to meet eligibility criteria such as having a driver’s license, possessing minimum driving experience, health prerequisites, being part of a specific group, age, and gender. Procedures and tasks were not always described in detail. However, several studies described an initial moment where participants could familiarize themselves with the simulator without taking measurements, while fewer reported that participants were allowed to familiarize themselves with the tasks. Session length varied from eight to 90 minutes. Regarding the operationalization of distraction in experiments, some studies required drivers to perform a single type of distraction-inducing task (mental calculations, use of In-Vehicle Information System (IVIS), cell phone operation, and manual tasks) with varying difficulty levels. Still, most studies relied on a combination of different tasks, such as cell phone use, physical tasks (e.g., drinking, moving objects, and applying makeup), and IVIS use. Results showed studies favour the description of the digital systems over the experiment design and procedures and a preference for locating the studies at the individual level of analysis, precluding a broader understanding of human behaviour as socially constructed and signified. We argue that articulation with higher levels of analysis would bring relevant explanations for actual road behaviour and personal and social factors should be considered when developing driver monitoring systems aimed at reducing distraction. Our results may assist future studies within the same scope, guiding the definition of effective experimental designs to test artificial intelligence driving monitoring systems, while contributing to a more holistic understanding of driver’s behaviour. © 2023. Published by AHFE Open Access. All rights reserved.

Abstract Recent developments in vehicle automation are leading a paradigm change in respect to mobility of goods and people. Pushed by environmental concerns, researchers and practitioners seek new and innovative solutions. Nevertheless, the challenge of sustainable transport does not end with the use of clean fuels, as faster, cheaper, and more efficient transport is still desired by operators. The concepts behind truck automation and truck platooning technologies present potential for operations management efficiency and cost reduction. On the other hand, as drivers are still the main piece on a safe and efficient transport system, their working conditions must be ensured. Therefore, a multidisciplinary perspective on truck platooning is required, comprising the view of all the stakeholders involved in the development of safe and easily adopted technologies. In the context of the project TRAIN, we have developed exploratory research towards understanding and mapping the requirements for deploying truck platooning technology. Through a qualitative research, based on focus groups, we have identified three main areas of requirements from logistics companies: (i) labor, (ii) safety and liability, and (iii) transport and logistics. The analysis also showed that these areas are related to three research domains: (i) human factors and human-machine interaction, (ii) operations research and management, and (iii) policy and regulation. © 2023. Published by AHFE Open Access. All rights reserved.

Abstract Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial molecular chaperone that contributes to the maintenance of mitochondrial integrity by decreasing the production and accumulation of ROS. The present study aimed to evaluate the presence and the role of TRAP1 in the RPE. Here, we report that TRAP1 is expressed in human adult retinal pigment epithelial cells and is located mainly in the mitochondria. Exposure of RPE cells to hydrogen peroxide decreases the levels of TRAP1. Furthermore, TRAP1 silencing increases intracellular ROS production and decreases mitochondrial respiratory capacity without affecting cell proliferation. Together, these findings offer novel insights into TRAP1 functions in RPE cells, opening possibilities to develop new treatment options for AMD.

Abstract Chronic diseases represent one of the major causes of death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM), maternal obesity (MO), and intra-uterine growth restriction (IUGR) induce an adverse intrauterine environment, increasing the offspring's predisposition to chronic diseases later in life. Research has suggested that mitochondrial function and oxidative stress may play a role in the developmental programming of chronic diseases. Having this in mind, in this review, we include evidence that mitochondrial dysfunction and oxidative stress are mechanisms by which GDM, MO, and IUGR program the offspring to chronic diseases. In this specific context, we explore the promising advantages of maternal antioxidant supplementation using compounds such as resveratrol, curcumin, N-acetylcysteine (NAC), and Mitoquinone (MitoQ) in addressing the metabolic dysfunction and oxidative stress associated with GDM, MO, and IUGR in fetoplacental and offspring metabolic health. This approach holds potential to mitigate developmental programming-related risk of chronic diseases, serving as a probable intervention for disease prevention.

Abstract In this work, we intend to reflect on digital media in science and ma- thematics teaching from theoretical readings and empirical works that consider, mainly, the Portuguese case. First, we will situate the debate in the internal con- tradictions of the representations of the school and the idea of crisis associated with digital media. Then we will address the problems specifically associated with the Internet and the way in which it is integrated into pedagogical practices and, subsequently, into the participatory culture. We will see how the gap between promises and reality is constant and significant. We will end our work with a brief reflection in which we call on those responsible for education to reflect on the role of the school in the appropriation of digital media and the Internet.

Abstract Background: Patients with immune-mediated inflammatory diseases (IMIDs) treated with immunomodulatory therapy present an increased susceptibility to infections. Vaccination is a crucial element in the management of IMID patients; however, rates remain suboptimal. This study intended to clarify the adherence to prescribed vaccines. Materials and methods: This prospective cohort study included 262 consecutive adults with inflammatory bowel disease and rheumatological diseases who underwent an infectious diseases evaluation before initiating or switching immunosuppressive/biological therapy. Vaccine prescription and adherence were assessed during an infectious diseases (ID) consultation using a real-world multidisciplinary clinical project. Results: At baseline, less than 5% had all their vaccines up-to-date. More than 650 vaccines were prescribed to 250 (95.4%) patients. The most prescribed were pneumococcal and influenza vaccines, followed by hepatitis A and B vaccines. Adherence to each of the vaccines ranged from 69.1-87.3%. Complete adherence to vaccines occurred in 151 (60.4%) patients, while 190 (76%) got at least two-thirds of them. Twenty patients (8%) did not adhere to any of the vaccines. No significant differences were found in the adherence rates of patients with different sociodemographic and health-related determinants. Conclusions: ID physicians can play a role in the process of increasing vaccine prescription and adherence. However, more data on patients' beliefs and vaccine hesitancy, along with mobilization of all health care professionals and adequate local interventions, shall be considered to improve vaccine adherence.

Abstract Background. No Man's Sky (NMS) is a sci-fi videogame about survival and exploration where players fly spaceships, search for elements, and use them to build, trade, and survive. Despite evolving around scientific concepts, NMS isn't a serious game, and not all the scientific content in the game is presented with evidence.Theory and Method. Looking at the interceptions between videogames and science, and moving to how science communication, both in theory and practice, can be explored within the videogame's paradigm, a survey was developed to better understand how NMS players perceive the scientific content in the game.Aims. Are players aware of the scientific content and how it is presented in NMS? Can they decipher it, question it and understand it under real-world rules? With the data collected from 124 respondents from 23 countries, we aim to better understand how an entertainment videogame can potentially help scientists, educators, and science communicators reach a growing, evolving, vibrant, diverse, and demanding audience.Results. Players seem aware of the scientific content in NMS, with a positive attitude through it. But players showed problems identifying what is right and wrong, while also pointing to the idea that every videogame that deals with science should strive to treat it with evidence. 57% of the respondents answered that NMS motivated them to know more about chemistry, with more than 35% revealing that they learned something new and understood the role of some scientific fundaments in certain real-world situations like new energy sources, biomes, or the role of carbon and oxygen.Discussion and Conclusion. With the growth of the videogames' audience, educators, science communicators, scientists, and policymakers can find in the medium - in any shape or form - a fun and interactive ally to engage with younger audiences and promote dialogues that can be transformative around scientific topics.