Showing: 10 from total: 14 publications
1. The mitochondria-targeted antioxidant AntiOxCIN4 protects against cardiac oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse
Mena, D ; Cagide, F ; Benfeito, S ; Soares, P ; Grilo, L ; Pinheiro, P ; Teixeira, J ; Borges, F ; Oliveira, PJ ; Duarte, AI
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2023, ISSN: 0014-2972,  Volume: 53, 
Abstract,  Indexed in: wos 
P-00Z-6BK
2. The mitochondria-targeted antioxidant AntiOxCIN4 attenuates brain and skeletal muscle oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse
Mena, D ; Soares, P ; Cagide, F ; Benfeito, S ; Grilo, L ; Silva, DF ; Pinheiro, P ; Ferreiro, E ; Teixeira, J ; Silva, F ; Borges, F ; Oliveira, PJ ; Duarte, AI
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2023, ISSN: 0014-2972,  Volume: 53, 
Abstract,  Indexed in: wos 
P-00Z-6A3
3. In vitro neuroprotective effects of dua-acting antiparkinsonians
Silva, V ; Benfeito, S ; Gil-Martins, E ; Costa, I ; Remião, F ; Borges, F ; Silva, R
in RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia, 2022, ISSN: 2184-4860,  Volume: 4, 
Article,  Indexed in: crossref 
DOI: 10.51126/revsalus.v4isup.396 P-00X-6YJ
4. New mitochondria-targeted antioxidants as promising drug candidates for the treatment of Parkinson's disease
Costa, I ; Benfeito, S ; Cagide, F ; Silva, V ; Borges, F ; Remiao, F ; Silva, R
in TOXICOLOGY LETTERS, 2022, ISSN: 0378-4274,  Volume: 368, 
Abstract,  Indexed in: crossref, wos 
DOI: 10.1016/j.toxlet.2022.07.803 P-00X-7YS
5. Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for amyotrophic lateral sclerosis
Soares, P ; Marques-Oliveira, R ; Alfenim, A ; Mena, D ; Fernandes, C ; Cagide, F ; Benfeito, S ; Silva, R ; Oliveira, P ; Duarte, AI ; Sousa, SF ; Borges, F
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, ISSN: 0014-2972,  Volume: 52, 
Abstract,  Indexed in: wos 
P-00W-Q9Z
6. The mitochondria-targeted antioxidant AntiOxCIN4 is beneficial against oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1(G3A) Mouse
Mena, D ; Soares, P ; Cagide, F ; Benfeito, S ; Grilo, L ; Silva, DF ; Valente, P ; Pinheiro, P ; Ferreiro, E ; Teixeira, J ; Silva, F ; Borges, F ; Oliveira, PJ ; Duarte, AI
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, ISSN: 0014-2972,  Volume: 52, 
Abstract,  Indexed in: wos 
P-00W-QA8
7. Mitochondriotropic Antioxidants Based on Hydroxycinnamic Acids Activates Nrf2-Mediated Cell Signalling Responses to Oxidative Stress: Implications in Non-Alcoholic Fatty Liver Disease (NAFLD)
Teixeira, J ; Amorim, R ; Simoes, I ; Cagide, F ; Potes, Y ; Soares, P ; Benfeito, S ; Pereira, SP ; Karkucinska-Wieckowska, A ; Szymanska, S ; Dabrowski, M ; Dobrzyn, A ; Jones, JG ; Borges, F ; Wieckowski, M ; Oliveira, PJ
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, ISSN: 0014-2972,  Volume: 52, 
Abstract,  Indexed in: wos 
P-00W-QAH
8. Mitochondriotropic antioxidant AntiOxCIN4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in western diet (WD)-fed mice
Amorim, R ; Simoes, ICM ; Teixeira, J ; Soares, P ; Potes, Y ; Cagide, F ; Benfeito, S ; Carvalho, A ; Pereira, SP ; Simoes, RF ; Borges, F ; Wieckowski, M ; Oliveira, PJ
in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2022, ISSN: 0014-2972,  Volume: 52, 
Abstract,  Indexed in: wos 
P-00W-QB5
9. Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles
Pinto, M ; Fernandes, C ; Gil Martins, E ; Silva, R ; Benfeito, S ; Cagide, F ; Borges, F ; Remiao, F
in TOXICOLOGY LETTERS, 2019, ISSN: 0378-4274,  Volume: 314, 
Abstract,  Indexed in: wos 
P-00R-2JZ
10. Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity
Ribeiro, JA ; Benfeito, S ; Cagide, F ; Teixeira, J ; Oliveira, PJ ; Borges, F ; Silva, AF ; Pereira, CM
in ANALYTICAL CHEMISTRY, 2018, ISSN: 0003-2700,  Volume: 90, 
Article,  Indexed in: crossref, scopus, wos 
DOI: 10.1021/acs.analchem.8b00787 P-00P-096
Abstract In this work, we report for the first time the accumulation activity by energized rat heart mitochondria and the ionic transfer process at a liquid liquid interface of a novel mitochondria-targeted antioxidant, named as AntiOxCIN(4), which is structurally based on a hydroxycinnamic acid. Lipophilicity studies conducted at the water/1,6-dichlorohexane (DCH) interface allowed the building up of an ionic partition diagram of AntiOxCIN(4) in accordance with the electrochemical data obtained. The partition coefficients of both positively charged (-2.3) and zwitterionic (0.2) forms of the antioxidant were determined. This study contributed to gaining an insight about the ability of the synthesized antioxidants to cross biomembrane barriers by using an interface between two immiscible electrolyte solutions (ITIES) as a model system.